Enantioselective activation of aldehydes by chiral phosphoric acid catalysts in an aza-ene-type reaction between glyoxylate and enecarbamate

Masahiro Terada, Kazuyo Soga, Norie Momiyama

研究成果: Article査読

126 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Double interaction doesit: Highly enantio- and diastereoselective aza-ene-type reaction of glyoxylate with an enecarbamate is accomplished by using a binol-derived phosphoric acid catalyst (see scheme). DFT computational analysis revealed that two hydrogen bonds formed between the catalyst and the aldehyde are critical for the high enantioselectivity.

本文言語English
ページ(範囲)4122-4125
ページ数4
ジャーナルAngewandte Chemie - International Edition
47
22
DOI
出版ステータスPublished - 2008 5 19

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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