Enantio- and Diastereoselective Synthesis of Latanoprost using an Organocatalyst

Genki Kawauchi, Shigenobu Umemiya, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

An enantioselective total synthesis of latanoprost was achieved. Its chiral cyclopentane core structure was constructed through an organocatalyst-mediated [3+2]-cycloaddition reaction, and chirality in the ω-side chain was generated by prolinate-anion-mediated α-aminoxylation of an aldehyde. Highly diastereoselective domino acetalization and an oxy-Michael reaction were key steps for the generation of C9 chirality.

本文言語English
ページ(範囲)8409-8414
ページ数6
ジャーナルChemistry - A European Journal
24
33
DOI
出版ステータスPublished - 2018 6 12

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

フィンガープリント 「Enantio- and Diastereoselective Synthesis of Latanoprost using an Organocatalyst」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル