Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus

Yurika Ikeda-Dantsuji, Hideaki Hanaki, Taiji Nakae, Yoshio Takesue, Kazunori Tomono, Junichi Honda, Katsunori Yanagihara, Hiroshige Mikamo, Kunihiko Fukuchi, Mitsuo Kaku, Shigeru Kohno, Yoshihito Niki

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.

本文言語English
ページ(範囲)2466-2468
ページ数3
ジャーナルAntimicrobial agents and chemotherapy
55
5
DOI
出版ステータスPublished - 2011 5月

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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