TY - JOUR
T1 - Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus
AU - Ikeda-Dantsuji, Yurika
AU - Hanaki, Hideaki
AU - Nakae, Taiji
AU - Takesue, Yoshio
AU - Tomono, Kazunori
AU - Honda, Junichi
AU - Yanagihara, Katsunori
AU - Mikamo, Hiroshige
AU - Fukuchi, Kunihiko
AU - Kaku, Mitsuo
AU - Kohno, Shigeru
AU - Niki, Yoshihito
PY - 2011/5
Y1 - 2011/5
N2 - Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.
AB - Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.
UR - http://www.scopus.com/inward/record.url?scp=79955526451&partnerID=8YFLogxK
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U2 - 10.1128/AAC.01548-10
DO - 10.1128/AAC.01548-10
M3 - Article
C2 - 21357291
AN - SCOPUS:79955526451
VL - 55
SP - 2466
EP - 2468
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 5
ER -
