Elimination of Pasteurella pneumotropica from a contaminated mouse colony by oral administration of enrofloxacin

Yutaka Ueno, Ritsuko Shimizu, Ryoko Nozu, Satoru Takahashi, Masayuki Yamamoto, Fumihiro Sugiyama, Akira Takakura, Toshio Itoh, Ken Ichi Yagami

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Enrofloxacin, a fluoroquinolone bactericidal antibiotic, was administered in an attempt to eradicate Pasteurella pneumotropica (P. pneumotropica) from a contaminated mouse colony. Contaminated mice, maintained within 4 animal rooms, were administered Enrofloxacin in drinking water at a daily dosage of 25.5 mg/kg for 2 weeks. Following one week of Enrofloxacin treatment, mice were selected randomly from each room and examined for P. pneumotropica. This procedure was repeated two or three times until all mice examined tested negative for the Pasteurella strain. With the exception of one room, treated mice consistently tested negative for P. pneumotropica for up to 45 weeks following completion of Enrofloxacin treatment. Thus, oral administration of Enrofloxacin significantly eliminated P. pneumotropica from a contaminated mouse colony.

本文言語English
ページ(範囲)401-405
ページ数5
ジャーナルExperimental Animals
51
4
DOI
出版ステータスPublished - 2002 7
外部発表はい

ASJC Scopus subject areas

  • 動物科学および動物学
  • 生化学、遺伝学、分子生物学(全般)
  • 獣医学(全般)

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