Elimination of Intracellular Bacteria by Autophagy

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Autophagy functions to eliminate several types of intracellular bacteria. Autophagy acts as the front line of innate immunity due to its rapid response to infection, but the mechanism of its induction is complicated. Upon infection of host cells by intracellular bacteria, autophagosomes form by targeting and recruiting the factors required to surround the bacteria. Several targeting pathways have been identified, including the ubiquitin-dependent pathway, the bacterial sensor-dependent pathway, and the damaged vacuole- dependent pathway, each of which functions through adapter proteins for autophagosome recruitment. Here we describe these pathways and discuss their role in the elimination of invasive bacteria.

本文言語English
ホスト出版物のタイトルAutophagy
ホスト出版物のサブタイトルCancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
出版社Elsevier Inc.
ページ203-210
ページ数8
3
ISBN(電子版)9780124055346
ISBN(印刷版)9780124055292
DOI
出版ステータスPublished - 2014 1 31

ASJC Scopus subject areas

  • 医学(全般)
  • 免疫学および微生物学(全般)

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