TY - JOUR
T1 - Electrophysiological mapping of the cochlear nucleus with multi-channel bipolar surface microelectrodes
AU - Oda, Kiyoshi
AU - Kawase, Tetsuaki
AU - Yamauchi, Daisuke
AU - Hidaka, Hiroshi
AU - Kobayashi, Toshimitsu
N1 - Funding Information:
This study was financially supported by a grant-in-aid from Ministry of Education, Culture, Sports, Science and Technology, Japan for fiscal 2006–2009.
PY - 2013/3
Y1 - 2013/3
N2 - Auditory potentials in response to electrical stimulation of the cochlear nucleus were recorded in guinea pigs using two types of multi-channel surface microelectrodes with inter-electrode distance of 100 and 200 μm. Unequivocal waves of electrically evoked auditory brainstem responses (EABRs), which increased in amplitude with increasing stimulation current, were consistently observed. Electrophysiological mapping with these multichannel electrodes could clearly distinguish stimulation points showing positive EABRs from points showing undetectable EABRs, indicating that multi-channel surface microelectrodes have great potential in clinical use to determine the optimal location for the positioning of auditory brainstem implants, and may allow more precise discrimination of pitch. Further study to clarify the optimal inter-electrode distance for humans is necessary before application to physiological mapping in the human cochlear nucleus.
AB - Auditory potentials in response to electrical stimulation of the cochlear nucleus were recorded in guinea pigs using two types of multi-channel surface microelectrodes with inter-electrode distance of 100 and 200 μm. Unequivocal waves of electrically evoked auditory brainstem responses (EABRs), which increased in amplitude with increasing stimulation current, were consistently observed. Electrophysiological mapping with these multichannel electrodes could clearly distinguish stimulation points showing positive EABRs from points showing undetectable EABRs, indicating that multi-channel surface microelectrodes have great potential in clinical use to determine the optimal location for the positioning of auditory brainstem implants, and may allow more precise discrimination of pitch. Further study to clarify the optimal inter-electrode distance for humans is necessary before application to physiological mapping in the human cochlear nucleus.
KW - 260-channel surface microelectrode
KW - Cochlear nucleus
KW - Electrically evoked auditory brainstem response
KW - Electrophysiological mapping
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U2 - 10.1007/s00405-012-2077-5
DO - 10.1007/s00405-012-2077-5
M3 - Article
C2 - 22692697
AN - SCOPUS:84878352821
VL - 270
SP - 869
EP - 874
JO - Archives of Oto-Rhino-Laryngology
JF - Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 3
ER -