TY - JOUR
T1 - Electron spin resonance study of the binding structures of cationic water-soluble metalloporphyrins on highly oriented deoxyribonucleic acid fibres
AU - Chikira, Makoto
AU - Suda, Shoichi
AU - Nakabayashi, Toyotaka
AU - Fujiwara, Yoshihito
AU - Ejiri, Takashi
AU - Yoshikawa, Mitsuhide
AU - Kobayashi, Nagao
AU - Shindo, Heisaburo
PY - 1995/12/1
Y1 - 1995/12/1
N2 - The binding structures of several paramagnetic metal complexes of 5,10,15,20-tetrakis(1-methyl-4-or -2-pyridinio) porphyrin (H2L 1 or H2L2) on the highly oriented DNA fibres were investigated by means of ESR spectroscopy and computer simulations of the spectra. The structural parameters characteristic of the sterospecific groove binding were obtained for [CuL2]Cl4, high-spin [FeCl(L1)]Cl4 and low-spin [CoL1] [ClO 4]4 and the low-spin monoimidazole adduct [CoL 1(Him)] [ClO4]4. They bind to the DNA with the normals of the porphyrin planes titled by about 45° from the double helix axes. The low-spin bis(imidazole) adduct [FeCl(L1) (Him) 2]Cl4 binds to A-form DNA with the porphyrin plane nearly parallel to the double helix axis. The complex [CoL1] [ClO 4]4 binds to DNA as an intercalator as well as a groove binder. It was also revealed that some metalloporphyrins stabilize the tertiary structures of DNA around the binding sites.
AB - The binding structures of several paramagnetic metal complexes of 5,10,15,20-tetrakis(1-methyl-4-or -2-pyridinio) porphyrin (H2L 1 or H2L2) on the highly oriented DNA fibres were investigated by means of ESR spectroscopy and computer simulations of the spectra. The structural parameters characteristic of the sterospecific groove binding were obtained for [CuL2]Cl4, high-spin [FeCl(L1)]Cl4 and low-spin [CoL1] [ClO 4]4 and the low-spin monoimidazole adduct [CoL 1(Him)] [ClO4]4. They bind to the DNA with the normals of the porphyrin planes titled by about 45° from the double helix axes. The low-spin bis(imidazole) adduct [FeCl(L1) (Him) 2]Cl4 binds to A-form DNA with the porphyrin plane nearly parallel to the double helix axis. The complex [CoL1] [ClO 4]4 binds to DNA as an intercalator as well as a groove binder. It was also revealed that some metalloporphyrins stabilize the tertiary structures of DNA around the binding sites.
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U2 - 10.1039/DT9950001325
DO - 10.1039/DT9950001325
M3 - Article
AN - SCOPUS:37049070099
SN - 1472-7773
SP - 1325
EP - 1331
JO - Dalton Transactions
JF - Dalton Transactions
IS - 8
ER -