Electrodeposition of anchored polypyrrole film on microelectrodes and stimulation of cultured cardiac myocytes

Matsuhiko Nishizawa, Hyuma Nozaki, Hirokazu Kaji, Takahiro Kitazume, Noriyuki Kobayashi, Takeshi Ishibashi, Takashi Abe

研究成果: Article査読

67 被引用数 (Scopus)

抄録

The electrically conducting polymer polypyrrole (PPy) was electrochemically deposited onto Pt microelectrodes on a polyimide (PI) substrate. Pre-modification of the PI surface with a self-assembled monolayer of octadecyltrichlorosilane-induced anisotropic lateral growth of PPy along the PI surface and enhanced adhesive strength of the PPy film. The lateral growth of PPy film around the electrode anchored the whole film to the substrate. External stimulation of cultured cardiac myocytes was carried out using the PPy-coated microelectrode. The myocytes on the microelectrode substrate were electrically conjugated to form a sheet, and showed synchronized beating upon stimulation. The threshold charge for effective stimulation of a 0.8 cm2 sheet of myocytes was around 0.2 μC, roughly corresponding to a membrane depolarization of 250 mV.

本文言語English
ページ(範囲)1480-1485
ページ数6
ジャーナルBiomaterials
28
8
DOI
出版ステータスPublished - 2007 3月

ASJC Scopus subject areas

  • バイオエンジニアリング
  • セラミックおよび複合材料
  • 生物理学
  • 生体材料
  • 材料力学

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