Electrochemical studies of danthron and the DNA-danthron interaction

Hui Zhou, Ziyi Sun, Tomonori Hoshi, Yoshitomo Kashiwagi, Junichi Anzai, Genxi Li

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Danthron is an important natural occurring component in laxative drugs. In this paper, electrochemical investigation of danthron and its interaction with DNA is reported. Via the electrochemical approach assisted by ultraviolet-visible (UV-Vis) spectroscopy, we have proved that danthron intercalates into DNA strands forming some nonelectroactive complexes, which results in the decrease of redox peak currents of danthron. In addition, the decrease of the peak currents is proportional to the concentration of DNA. The difference between the interaction of danthron with double-stranded DNA (dsDNA) and with single-stranded DNA (ssDNA) has also been studied. This character implies the potential of danthron to discriminate dsDNA and ssDNA.

本文言語English
ページ(範囲)21-26
ページ数6
ジャーナルBiophysical Chemistry
114
1
DOI
出版ステータスPublished - 2005 4月 1

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 有機化学

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