Electrochemical concentration of no-carrier-added [ 18F]fluoride from [ 18O]water in a disposable microfluidic cell for radiosynthesis of 18F-labeled radiopharmaceuticals

Hidekazu Saiki, Ren Iwata, Hiroaki Nakanishi, Rebecca Wong, Yoichi Ishikawa, Shozo Furumoto, Ryo Yamahara, Katsumasa Sakamoto, Eiichi Ozeki

研究成果: Article査読

30 被引用数 (Scopus)

抄録

The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [ 18F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [ 18F]fluoride was introduced into a disposable microfluidic cell (16μL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [ 18F]fluoride was released in MeCN containing Kryptofix ® 222-KHCO 3 (ca. 60μL) under heat and a reversed potential (-2.5V). An automated module provided the [ 18F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.

本文言語English
ページ(範囲)1703-1708
ページ数6
ジャーナルApplied Radiation and Isotopes
68
9
DOI
出版ステータスPublished - 2010 9 1

ASJC Scopus subject areas

  • Radiation

フィンガープリント 「Electrochemical concentration of no-carrier-added [ <sup>18</sup>F]fluoride from [ <sup>18</sup>O]water in a disposable microfluidic cell for radiosynthesis of <sup>18</sup>F-labeled radiopharmaceuticals」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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