Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films

Samad Ahadian, Javier Ramón-Azcón, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini

研究成果: Article査読

45 被引用数 (Scopus)

抄録

The electrical conductivity of graphene provides a unique opportunity to modify the behavior of electrically sensitive cells. Here, we demonstrate that C2C12 myoblasts that were cultured on ultrathin thermally reduced graphene (TR-Graphene) films had more favorable cell adhesion and spreading compared to those on graphene oxide (GO) and glass slide substrates, comparable with conventional Petri dish. More importantly, we demonstrate that electrical stimulation significantly enhanced myoblast cell differentiation on a TR-Graphene substrate compared to GO and glass slide surfaces as confirmed by the expression of myogenic genes and proteins. These results highlight the potential applications of graphene-based materials for cell-based studies, bioelectronics, and biorobotics.

本文言語English
ページ(範囲)9534-9541
ページ数8
ジャーナルRSC Advances
4
19
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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