The recent progress of highly selective titanium reagents in organic synthesis is reviewed. The use of titanium reagents is classified into the following six categories: (1) Bi-metallic reagents of titanium and main group elements, aluminum in particular, for olefination. (2) Alkyltitanium reagents for carbon-carbon bond formation. (3) Titanium enolates for aldol condensation. (4) Chiral titanium complexes for asymmetric Lewis-acid catalysis. (5) Low valent titanium reagents for reductive coupling reaction. (6) Sharpless reagent for asymmetric epoxidation.
ASJC Scopus subject areas
- Organic Chemistry