Efficient generation of reactive oxygen species sonochemically generated by cavitation bubbles

Jun Yasuda, Shin Yoshizawa, Shin Ichiro Umemura

研究成果: Conference contribution

抄録

Background: Sonodynamic treatment is a cancer treatment method using by cavitation bubbles generated by ultrasound. In sonodynamic treatment, generating ROS efficiently by cavitation bubbles at target cancerous tissue is important. Objective: The aim of this paper is generating ROS efficiently by using exposure sequence which have short, high-intensity ultrasound pulse (triggered pulse) immediate followed by long, moderately low-intensity ultrasound burst (sustaining waves). Experiment: Cavitation bubbles were generated by using two sequences. The firsts sequence had both of triggered pulse and sustaining waves. The second one had only triggered pulse. After ultrasound exposure finished, the amount of ROS was quantified by KI method. Result and conclusion: The sequence which had both trigger pulse and sustaining waves generated ROS more efficient than the sequence which had only triggered pulse. The reason of this result is that sustaining waves oscillated cavitation bubbles volumetrically which were generated by triggered pulse and such volume oscillation of bubbles by sustaining waves contributes for efficient generation of ROS.

本文言語English
ホスト出版物のタイトル2015 IEEE International Ultrasonics Symposium, IUS 2015
出版社Institute of Electrical and Electronics Engineers Inc.
ISBN(電子版)9781479981823
DOI
出版ステータスPublished - 2015 11 13
イベントIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
継続期間: 2015 10 212015 10 24

出版物シリーズ

名前2015 IEEE International Ultrasonics Symposium, IUS 2015

Other

OtherIEEE International Ultrasonics Symposium, IUS 2015
国/地域Taiwan, Province of China
CityTaipei
Period15/10/2115/10/24

ASJC Scopus subject areas

  • 音響学および超音波学

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