Efficient generation of cavitation bubbles in gel phantom by ultrasound exposure with negative-followed by positive-peak-pressure-emphasized waves

Jun Yasuda, Ayumu Asai, Shin Yoshizawa, Shin Ichiro Umemura

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Cavitation bubbles have much potential for emphasizing therapeutic treatments such as high-intensity focused ultrasound (HIFU) treatment, histotripsy, and sonodynamic therapy. Their highly efficient as well as controlled generation is important to utilize them effectively as well as safely. However, producing negative pressure over the cavitation threshold by focused ultrasound is difficult because of the nonlinear propagation combined with the focal phase shift. We have suggested a dual-frequency ultrasound exposure method, in which N- and P-waves emphasizing either the peak negative or positive pressure, respectively, are synthesized by superimposing the second harmonic onto the fundamental frequency. In this study, high-speed camera observation demonstrated that the exposure with N-waves immediately followed by P-waves could generate cavitation bubbles most efficiently in gel phantom. Furthermore, the measured negative and positive pressure distributions of the N- and P-wave fields, respectively, agreed well with the optically observed distributions of cavitation inception and cavitation cloud growth.

本文言語English
論文番号07HF11
ジャーナルJapanese journal of applied physics
52
7 PART 2
DOI
出版ステータスPublished - 2013 7

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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