Efficient generation of cavitation bubbles and reactive oxygen species using triggered high-intensity focused ultrasound sequence for sonodynamic treatment

Jun Yasuda, Shin Yoshizawa, Shin Ichiro Umemura

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Sonodynamic treatment is a method of treating cancer using reactive oxygen species (ROS) generated by cavitation bubbles in collaboration with a sonosensitizer at a target tissue. In this treatment method, both localized ROS generation and ROS generation with high efficiency are important. In this study, a triggered high-intensity focused ultrasound (HIFU) sequence, which consists of a short, extremely high intensity pulse immediately followed by a long, moderate-intensity burst, was employed for the efficient generation of ROS. In experiments, a solution sealed in a chamber was exposed to a triggered HIFU sequence. Then, the distribution of generated ROS was observed by the luminol reaction, and the amount of generated ROS was quantified using KI method. As a result, the localized ROS generation was demonstrated by light emission from the luminol reaction. Moreover, it was demonstrated that the triggered HIFU sequence has higher efficiency of ROS generation by both the KI method and the luminol reaction emission.

本文言語English
論文番号07KF24
ジャーナルJapanese journal of applied physics
55
7
DOI
出版ステータスPublished - 2016 7

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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