Efficient approach to the oppolzer-kametani intermediate for estrone methyl ether using the conjugate addition-enolate methylation of the cyclopentenone containing an α-appended benzocyclobutane moiety

Takashi Takahashi, Katsuya Shimizu, Takayuki Doi, Jiro Tsuji, Keiji Yamamoto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Simple synthesis of (±)-estrone methyl ether by the conjugate addition-enolate methylation of the 2-alkylcyclopentenone followed by the intramolecular Diels-Alder reaction of the o-quinodimethane, and discussions for the diastereoselectivity in the enolatemethylation based on the MM2 transition structure model are presented.

本文言語English
ページ(範囲)4999-5002
ページ数4
ジャーナルTetrahedron Letters
30
37
DOI
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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