Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A

Shuji Yamashita, Kazuki Kitajima, Kentaro Iso, Masahiro Hirama

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The highly stereoselective attachment of isoquinoline onto the steroidal framework of cortistatin A has been achieved. Our strategy features a Ce-mediated nucleophilic addition of an isoquinoline unit to the sterically congested ketone followed by formation of the phenyl thiocarbamate, and subsequent stereoselective radical reduction. The new method results in a formal total synthesis of cortistatin A.

本文言語English
ページ(範囲)3277-3279
ページ数3
ジャーナルTetrahedron Letters
50
26
DOI
出版ステータスPublished - 2009 7 1

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル