Efficacy of recombinant human soluble thrombomodulin in severe postpartum hemorrhage with disseminated intravascular coagulation

Junichi Sugawara, Kaori Suenaga, Tetsuro Hoshiai, Takahiro Sato, Hidekazu Nishigori, Satoru Nagase, Nobuo Yaegashi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Objective: To investigate the efficacy of recombinant human soluble thrombomodulin (rTM) in disseminated intravascular coagulation (DIC) associated with severe postpartum hemorrhage (PPH). Patients and Methods: We conducted a retrospective review of 36 patients with severe PPH complicated by DIC admitted to a single tertiary center. The first 26 patients were treated without rTM (control group), and the next 10 consecutive patients were treated with rTM. Clinical parameters including bleeding symptoms and coagulation indices were evaluated. Results: Baseline characteristics, total blood loss, and transfusion requirements were similar between the 2 groups. On day 2, there was a significant difference between the 2 groups in the decrease in D-dimer level from baseline. The incidence of bleeding symptoms was decreased in the rTM group compared with the control group. No adverse events were observed in the rTM group. Conclusion: Recombinant human thrombomodulin may be an effective adjunctive therapy in the management of DIC related to PPH.

本文言語English
ページ(範囲)557-561
ページ数5
ジャーナルClinical and Applied Thrombosis/Hemostasis
19
5
DOI
出版ステータスPublished - 2013 9

ASJC Scopus subject areas

  • Hematology

フィンガープリント 「Efficacy of recombinant human soluble thrombomodulin in severe postpartum hemorrhage with disseminated intravascular coagulation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル