Efficacy of pazufloxacin mesilate in Legionnaires' disease: A case report and in vitro study of the isolate

Futoshi Higa, Takashi Shinzato, Masato Toyama, Shusaku Haranaga, Makoto Furugen, Masao Tateyama, Kazuyoshi Kawakami, Atsushi Saito

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We report here a case of culture-proven Legionnaires' disease successfully treated with intravenous injection of pazufloxacin mesilate (PZFX), a fluoroquinolone newly approved in Japan. The patient was a 51-year-old man hospitalized after a diagnosis of community-acquired pneumonia. Legionella pneumophila SG1 was isolated from the patient's bronchoalveolar lavage (BAL) fluid, and the soluble antigen of the bacterium was detected in the fluid as well. Subsequently, intravenous PZFX was administered for a week and proved markedly effective. An in vitro study confirmed that PZFX had excellent extracellular and intracellular activity against the isolate from the patient. This case suggests that PZFX is an option for treating Legionnaires' disease.

本文言語English
ページ(範囲)164-168
ページ数5
ジャーナルJournal of Infection and Chemotherapy
11
3
DOI
出版ステータスPublished - 2005 6月
外部発表はい

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

フィンガープリント

「Efficacy of pazufloxacin mesilate in Legionnaires' disease: A case report and in vitro study of the isolate」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル