TY - JOUR
T1 - Efficacy of pazufloxacin mesilate in Legionnaires' disease
T2 - A case report and in vitro study of the isolate
AU - Higa, Futoshi
AU - Shinzato, Takashi
AU - Toyama, Masato
AU - Haranaga, Shusaku
AU - Furugen, Makoto
AU - Tateyama, Masao
AU - Kawakami, Kazuyoshi
AU - Saito, Atsushi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/6
Y1 - 2005/6
N2 - We report here a case of culture-proven Legionnaires' disease successfully treated with intravenous injection of pazufloxacin mesilate (PZFX), a fluoroquinolone newly approved in Japan. The patient was a 51-year-old man hospitalized after a diagnosis of community-acquired pneumonia. Legionella pneumophila SG1 was isolated from the patient's bronchoalveolar lavage (BAL) fluid, and the soluble antigen of the bacterium was detected in the fluid as well. Subsequently, intravenous PZFX was administered for a week and proved markedly effective. An in vitro study confirmed that PZFX had excellent extracellular and intracellular activity against the isolate from the patient. This case suggests that PZFX is an option for treating Legionnaires' disease.
AB - We report here a case of culture-proven Legionnaires' disease successfully treated with intravenous injection of pazufloxacin mesilate (PZFX), a fluoroquinolone newly approved in Japan. The patient was a 51-year-old man hospitalized after a diagnosis of community-acquired pneumonia. Legionella pneumophila SG1 was isolated from the patient's bronchoalveolar lavage (BAL) fluid, and the soluble antigen of the bacterium was detected in the fluid as well. Subsequently, intravenous PZFX was administered for a week and proved markedly effective. An in vitro study confirmed that PZFX had excellent extracellular and intracellular activity against the isolate from the patient. This case suggests that PZFX is an option for treating Legionnaires' disease.
KW - Fluoroquinolone
KW - Legionella pneumophila
KW - Legionnaires' disease
KW - Pazufloxacin mesilate
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U2 - 10.1007/s10156-005-0381-3
DO - 10.1007/s10156-005-0381-3
M3 - Article
C2 - 15990982
AN - SCOPUS:21644443070
VL - 11
SP - 164
EP - 168
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 3
ER -
