Efficacy of a device-based continuous optimization algorithm for patients with cardiac resynchronization therapy

Nobuhiko Ueda, Takashi Noda, Kohei Ishibashi, Kenzaburo Nakajima, Naoya Kataoka, Tsukasa Kamakura, Mitsuru Wada, Kenichiro Yamagata, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takeshi Aiba, Hideaki Kanzaki, Chisato Izumi, Teruo Noguchi, Satoshi Yasuda, Kengo Kusano

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Cardiac resynchronization therapy (CRT) is less effective in patients with mildly wide QRS or non-left bundle branch block (non-LBBB). A new algorithm of every minute's optimization (adaptive CRT: ACRT algorithm) is effective in patients with CRT devices. This study investigated the clinical effect of the aCRT algorithm, especially in mildly wide QRS (120≤QRS<150 ms) or non- LBBB patients receiving CRT. Methods and Results: This study included 104 CRT patients (48 patients using the aCRT algorithm [adaptive group] and 56 patients not using the aCRT algorithm [non-adaptive group]). The primary endpoint was a composite clinical outcome of cardiac death and/or heart failure (HF) hospitalization. During a median follow-up of 700 days (interquartile range 362-1,173 days), aCRT reduced the risk of the clinical outcome, even in patients with mildly wide QRS or non-LBBB (log-rank P=0.0030 and P=0.0077, respectively) by Kaplan-Meier analysis. Use of the aCRT algorithm was an independent predictor of clinical outcomes in the multivariate analysis (hazard ratio (HR) 0.28, 95% confidence interval (CI): 0.096-0.78, P=0.015), the same as in patients with mildly wide QRS (HR 0.12, 95% CI: 0.006-0.69, P=0.015). Conclusions: The new aCRT algorithm was useful and significantly reduced the risk of the clinical outcome, even in patients with mildly wide QRS.

本文言語English
ページ(範囲)18-25
ページ数8
ジャーナルCirculation Journal
84
1
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 循環器および心血管医学

フィンガープリント

「Efficacy of a device-based continuous optimization algorithm for patients with cardiac resynchronization therapy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル