Effects of the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) on bacterial viability and metabolism

Naomi Izutani, Satoshi Imazato, Kazuko Nakajo, Nobuhiro Takahashi, Yusuke Takahashi, Shigeyuki Ebisu, Roy R.B. Russell

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) is a strong bactericide when unpolymerized and has the potential to be utilized in various resinous biomaterials. To analyze the antibacterial characteristics of this monomer in detail, the ability of high concentrations of unpolymerized MDPB to kill Streptococcus mutans in planktonic or biofilm forms within a short time-period of contact, and the inhibitory effects of low concentrations of MDPB on the metabolic function of S. mutans, were examined. High concentrations of MDPB showed effective killing of planktonic and biofilm S. mutans cells within 60s, and complete killing was obtained by contact with 1,000μgml-1 of MDPB for 60s. At a concentration of 4-8μgml-1, MDPB demonstrated growth inhibition, inducing elongation of the lag phase and of the doubling time, when the bacterial number was low. Inhibition of the production of acid from S. mutans by 8μgml-1 of MDPB may have been caused by the inhibition of lactate dehydrogenase activity. At high concentrations, MDPB is lethal to both planktonic and biofilm forms of S. mutans in a short time-period, and at low concentrations, MDPB inhibits metabolic enzymatic activity.

本文言語English
ページ(範囲)175-181
ページ数7
ジャーナルEuropean Journal of Oral Sciences
119
2
DOI
出版ステータスPublished - 2011 4

ASJC Scopus subject areas

  • Dentistry(all)

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