Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Chihiro Ito, Haowei Shen, Hiroshi Toyota, Yasuhiko Kubota, Eiko Sakurai, Takehiko Watanabe, Mitsumoto Sato

研究成果: Article査読

40 被引用数 (Scopus)

抄録

The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

本文言語English
ページ(範囲)143-145
ページ数3
ジャーナルNeuroscience Letters
262
2
DOI
出版ステータスPublished - 1999 3 5

ASJC Scopus subject areas

  • 神経科学(全般)

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