Effects of ruminal infusion of volatile fatty acids on plasma concentration of growth hormone and insulin in sheep

N. Matsunaga, N. T. Arakawa, T. Goka, K. T. Nam, A. Ohneda, Y. Sasaki, Kazuo Katoh

    研究成果: Article査読

    28 被引用数 (Scopus)

    抄録

    In an initial experiment we observed postprandial changes in plasma concentrations of growth hormone (GH), insulin, glucagon, and somatostatin (SRIF) in sheep. We then examined whether increasing the rumen concentration of volatile fatty acids (VFA) by infusing a VFA mixture at three rates (53.5, 107, and 214 μmol/kg/min for 4 hr) mimicked the postprandial changes in hormone secretion. Feeding significantly (P < 0.05) suppressed the plasma GH concentration for 6 hr, whereas it significantly (P < 0.05) increased plasma concentrations of insulin, glucagon, and SRIF. Plasma glucose levels tended to decrease after feeding but then gradually increased over the prefeeding level (P < 0.05). Intraruminal infusion of the VFA mixture at 107 μmol/kg/min caused similar changes in ruminal VFA concentrations to those seen after feeding. The infusion significantly (P < 0.05) suppressed GH secretion in a dose-dependent manner, whereas it caused a significant (P < 0.05) increase in insulin and glucose concentrations without changing glucagon concentrations. From these results, we conclude that the postprandial change in ruminal VFA concentration may be a physiological signal which modifies GH and insulin secretion in sheep.

    本文言語English
    ページ(範囲)17-27
    ページ数11
    ジャーナルDomestic Animal Endocrinology
    17
    1
    DOI
    出版ステータスPublished - 1999 7月 1

    ASJC Scopus subject areas

    • 食用動物
    • 動物科学および動物学
    • 内分泌学

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