Effects of Rhinovirus Infection on the Adherence of Streptococcus pneumoniae to Cultured Human Airway Epithelial Cells

Satoshi Ishizuka, Mutsuo Yamaya, Tomoko Suzuki, Hidenori Takahashi, Shiroh Ida, Takahiko Sasaki, Daisuke Inoue, Kiyohisa Sekizawa, Hidekazu Nishimura, Hidetada Sasaki

研究成果: Article査読

125 被引用数 (Scopus)

抄録

To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-κB (NF-κB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-κB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.

本文言語English
ページ(範囲)1928-1939
ページ数12
ジャーナルJournal of Infectious Diseases
188
12
DOI
出版ステータスPublished - 2003 12 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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