Effects of Nd:YAG laser irradiation on morphometry and lung function in elastase-induced emphysema in rats

Tsutomu Akahane, Yoshimochi Kurokawa, Ryoji Chiba, Hiroshi Yaegashi, Tohru Takahashi, Susumu Satomi

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Background and Objective: Although thoracoscopic laser ablation therapy has been hailed as an effective surgical treatment for diffuse emphysema, no one has as yet made an in-depth study of the efficacy of this treatment. This investigation was undertaken to research the effects of laser pneumoplasty on an animal model of emphysema. Study Design /Materials and Methods: Eight weeks after elastase treatment, the rats' left lungs were irradiated using contact Nd:YAG laser. Pulmonary function tests were performed 4 weeks after irradiation and the lungs were prepared for histologic examination. Results: Dense fibrous scars beneath the pleura were observed at 4 weeks after irradiation. Although mean linear intercept values of irradiated lungs were not much lower than those in the non-irradiated elastase-treated group, laser irradiation caused a significant decrease in lung volume. While there was no significant difference in quasistatic compliance, elastic recoil pressure of the lung increased to control levels at total lung capacity volume. Conclusion: We conclude that laser therapy does not cause normalization of compliance, or improvement in the deeper part of the emphysematous lung, but rather a peripheral volume reduction and 'encasement effect' on the lungs as a result of fibrotic scars.

本文言語English
ページ(範囲)204-212
ページ数9
ジャーナルLasers in Surgery and Medicine
23
4
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 外科
  • 皮膚病学

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