Effects of nano-hydroxyapatite content on bone formation in nano-hydroxyapatite-collagen composite membrane with BMP-2 application

Taichi Tenkumo, Tsutomu Sugaya, Masamitsu Kawanami, Fumio Watari

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The effects of calcium and phosphate contents on bone formation activity by BMP-2 with nano-hydroxyapatite-collagen composites (nHACs) were evaluated. Nanosize crystallites with different concentrations of hydroxyapatite were successfully fabricated by changing the mixing ratio of calcium solution and phosphate-containing neutralization buffer. Composites were implanted into the subcutaneous tissue in the Wistar male rats with BMP-2 for 2 and 4 weeks. nHAC was degraded and inflammation in the surrounding area decreased with time. Ectopic bone formation was observed around nHACs with higher contents of nano-hydroxyapatite in BMP-2 application at 2 weeks, but was not observed with lower contents at 4 weeks. These results suggest that nHAC with a higher content of nano-hydroxyapatite is suitable as a carrier for BMP-2.

本文言語English
ページ(範囲)159-166
ページ数8
ジャーナルNano Biomedicine
1
2
出版ステータスPublished - 2009 12月 1
外部発表はい

ASJC Scopus subject areas

  • 生体医工学

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