抄録
The effects of calcium and phosphate contents on bone formation activity by BMP-2 with nano-hydroxyapatite-collagen composites (nHACs) were evaluated. Nanosize crystallites with different concentrations of hydroxyapatite were successfully fabricated by changing the mixing ratio of calcium solution and phosphate-containing neutralization buffer. Composites were implanted into the subcutaneous tissue in the Wistar male rats with BMP-2 for 2 and 4 weeks. nHAC was degraded and inflammation in the surrounding area decreased with time. Ectopic bone formation was observed around nHACs with higher contents of nano-hydroxyapatite in BMP-2 application at 2 weeks, but was not observed with lower contents at 4 weeks. These results suggest that nHAC with a higher content of nano-hydroxyapatite is suitable as a carrier for BMP-2.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 159-166 |
| ページ数 | 8 |
| ジャーナル | Nano Biomedicine |
| 巻 | 1 |
| 号 | 2 |
| 出版ステータス | Published - 2009 12月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 生体医工学