Effects of local osteoprotegerin gene transfection on orthodontic root resorption during retention: An in vivo micro-CT analysis

N. Zhao, Y. Liu, H. Kanzaki, W. Liang, J. Ni, J. Lin

    研究成果: Article査読

    19 被引用数 (Scopus)

    抄録

    Objectives- External root resorption (ERR) is a serious complication of orthodontic treatment. Aim of this study was to evaluate the effects of local osteoprotegerin (OPG) gene transfection on ERR during retention. Material and Methods- Eighteen 6-week-old male Wistar rats were divided into three groups. All the rats were subjected to 2weeks of orthodontic tooth movement followed by a 2-week retention period. During retention, the three groups of rats received local OPG gene transfection (OPG transfection group, n=6), mock vector transfection (mock group, n=6), or no injections (control group, n=6). ERR of all three groups was evaluated with in vivo micro-CT analysis at three different time points: baseline, the last day of orthodontic tooth movement, and the last day of retention. Results- In the OPG transfection group, there was no significant difference between ERR at the baseline and ERR on the last day of retention. By the last day of retention, the repair ratio of ERR in the OPG transfection group was statistically higher in relation to the repair ratio of the other groups (p<0.001). Conclusion- The results indicated that local OPG gene transfection significantly enhanced the repair of ERR during retention. Local OPG gene transfection might therefore be a useful tool for ERR repair during retention.

    本文言語English
    ページ(範囲)10-20
    ページ数11
    ジャーナルOrthodontics and Craniofacial Research
    15
    1
    DOI
    出版ステータスPublished - 2012 2

    ASJC Scopus subject areas

    • 歯科矯正学
    • 外科
    • 口腔外科
    • 耳鼻咽喉科学

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