Effects of glucose on formation of cytotoxic end-products and proteolytic activity of Prevotella intermedia, Prevotella nigrescens and Porphyromonas gingivalis

Kaoru Saito, Nobuhiro Takahashi, Hiroshi Horiuchi, Tadashi Yamada

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Black-pigmented bacteria which produce cytotoxic metabolic end-products and cell membrane-associated proteases have been reported to play an important role in the pathogenesis of periodontal diseases. These bacterial virulence factors can be modified by the environmental conditions including nutrients supplied variously into the oral cavity. Although glucose is one of the most essential nutrients for oral bacteria, the exogenous supply of glucose may be discontinuous and the glucose concentration in a periodontal pocket may be influenced by the depth of the periodontal pocket. Therefore, effects of glucose as an environmental factor on the virulence factors of Prevotella intermedia, Prevotella nigrescens and Porphyromonas gingivalis were studied. When grown in the presence of glucose, both P. intermedia and P. nigrescens markedly decreased the production of cytotoxic end-products including succinate, isobutyrate, isovalerate and ammonia, although their growth was increased. Furthermore, the proteolytic activities such as immunoglobulin-, albumin- and casein-degrading activities of these bacteria were decreased in the presence of glucose. On the other hand, no effect of glucose on the metabolic activity of P. gingivalis was observed. These results suggest that pathogenicity of P. intermedia and P. nigrescens may be decreased by the presence of glucose.

本文言語English
ページ(範囲)355-360
ページ数6
ジャーナルJournal of Periodontal Research
36
6
DOI
出版ステータスPublished - 2001 12

ASJC Scopus subject areas

  • 歯周病学

フィンガープリント

「Effects of glucose on formation of cytotoxic end-products and proteolytic activity of Prevotella intermedia, Prevotella nigrescens and Porphyromonas gingivalis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル