Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma an immunohistochemical study of vasohibin-1 and CD31 with correlation to pathobiological response of the patients in neoadjuvant aromatase inhibitor therapy

Monica Sm Chan, Lin Wang, Niramol Chanplakorn, Kentaro Tamaki, Takayuki Ueno, Masakazu Toi, Wings Ty Loo, Louis Wc Chow, Takashi Suzuki, Hironobu Sasano

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Objectives: Tumorstroma interactions, including angiogenesis, are pivotal in breast cancer. Changes of angiogenesis during endocrine therapy have not been reported in breast cancer patients. Vasohibin-1 (VASH-1) is a recently identified endothelium-derived negative feedback regulator of angiogenesis. Vasohibin-1 positive ratio (VPR) is proposed as an indicator of neovascularization of the tissues. Methods: The status of neovascularization, based on VPR before and after steroidal aromatase inhibitor (AI) exemestane (EXE) treatment, was evaluated in 54 post-menopausal Asian patients. VPR changes were correlated with the pathobiological response of the patients using Ki67 labeling index (LI) changes. Results: When using a decrement of more than 40% in post-treatment Ki67 LI as the definition of response, significant inverse correlation was detected between Ki67 LI and VPR changes in responders. Significant increment in neovascularization, as demonstrated by elevated VPR, was only detected in responders (p = 0.039). Increased angiogenesis detected in responders to neoadjuvant therapy may represent a stromal response to dying/dead cells, as part of tumorstroma interaction following estrogen depletion. Conclusions: VPR could be a potential surrogate marker for predicting neoadjuvant endocrine therapy response, incorporating features of both carcinoma and stromal cells, in the early stage of neoadjuvant endocrine therapy before any discernible clinical and/or histopathological changes became apparent.

本文言語English
ページ(範囲)S69-S78
ジャーナルExpert Opinion on Therapeutic Targets
16
SUPPL. 1
DOI
出版ステータスPublished - 2012 3

ASJC Scopus subject areas

  • 分子医療
  • 薬理学
  • 創薬
  • 臨床生化学

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