Effects of energy restriction on age-associated changes of DNA methylation in mouse liver

Yoshinori Miyamura, Riichi Tawa, Akio Koizumi, Yoshihiko Uehara, Akihiro Kurishita, Hiromu Sakurai, Shigetoshi Kamiyama, Tetsuya Ono

研究成果: Article査読

25 被引用数 (Scopus)

抄録

DNA methylation is known to change with age in several mammalian species. Here we have examined the effect of dietary energy restriction on this age-associated change in liver DNA of C3H/SHN mice. The total 5-methyldeoxycytidine level in the genome decreased slightly soon after energy restriction started. The effect, however, diminished with time and no appreciable difference was detected at middle and old ages. The degree of methylation at the c-myc gene, on the other hand, was not affected by energy restriction at early periods, but the age-dependent alterations at later ages were repressed. This is a new finding to show that DNA methylation is one of the molecular indices of aging affected by energy restriction. It suggests an importance of DNA methylation in the aging process.

本文言語English
ページ(範囲)63-69
ページ数7
ジャーナルMutation Research DNAging
295
2
DOI
出版ステータスPublished - 1993 3

ASJC Scopus subject areas

  • Ageing
  • Molecular Biology
  • Genetics

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