TY - JOUR
T1 - Effects of chlordimeform on the electrical activity of waxmoth larva foregut
AU - Yamamoto, Daisuke
AU - Fukami, Jun ichi
PY - 1979/8
Y1 - 1979/8
N2 - Microelectrodes were used to study the action of chlordimeform on the foregut nerve-muscle system of waxmoth larvae, Galleria mellonella. Excitatory postsynaptic potentials evoked by nerve stimulation were reversibly depressed by 2 × 10-3M chlordimeform. All-or-none spikes elicited by transmembrane current pulses were affected by higher concentrations (up to 5 × 10-3M) of chlordimeform. The critical membrane potential for spiking was always increased, while in some cases the amplitude and the rate of rise of the spike was reduced. Chlordimeform at 5 × 10-3M had very little effect on the outward rectification and effective membrane resistance of these muscle fibers. These data suggest the primary action of chlordimeform, causing a disturbance of foregut activity, is an inhibition of the mechanisms which generate synaptic and action potentials.
AB - Microelectrodes were used to study the action of chlordimeform on the foregut nerve-muscle system of waxmoth larvae, Galleria mellonella. Excitatory postsynaptic potentials evoked by nerve stimulation were reversibly depressed by 2 × 10-3M chlordimeform. All-or-none spikes elicited by transmembrane current pulses were affected by higher concentrations (up to 5 × 10-3M) of chlordimeform. The critical membrane potential for spiking was always increased, while in some cases the amplitude and the rate of rise of the spike was reduced. Chlordimeform at 5 × 10-3M had very little effect on the outward rectification and effective membrane resistance of these muscle fibers. These data suggest the primary action of chlordimeform, causing a disturbance of foregut activity, is an inhibition of the mechanisms which generate synaptic and action potentials.
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U2 - 10.1016/0048-3575(79)90093-2
DO - 10.1016/0048-3575(79)90093-2
M3 - Article
AN - SCOPUS:0018672928
VL - 12
SP - 49
EP - 54
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
SN - 0048-3575
IS - 1
ER -