Effects of antifungal agent combinations administered simultaneously and sequentially against Aspergillus fumigatus

S. Maesaki, S. Kohno, M. Kaku, H. Koga, K. Hara

研究成果: Article査読

42 被引用数 (Scopus)

抄録

The in vitro effects of antifungal agent combinations administered simultaneously and sequentially against 15 strains of Aspergillus fumigatus were tested by the yeast-malt broth method. The synergistic effect of the combination of amphotericin B (AMPH) and miconazole was observed in nine strains (60%). However, the combinations of AMPH and fluconazole, AMPH and ketoconazole, and AMPH and itraconazole administered simultaneously showed antagonistic effects against three (20%), five (34%), and four (26%) strains, respectively. The effects of combinations of azole antifungal agents administered simultaneously were indifferent or antagonistic against A. fumigatus. In experiments measuring the effects of sequentially administered antifungal agents, however, pretreatment with AMPH and then azole antifungal agents exhibited better in vitro efficacy than that found in experiments measuring the effects of simultaneously administered AMPH and azole compounds.

本文言語English
ページ(範囲)2843-2845
ページ数3
ジャーナルAntimicrobial agents and chemotherapy
38
12
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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