Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

Atsushi Takahashi, Kenji Onodera, Takashi Saito, Masato Sugawara, Hisashi Shinoda, Hideaki Mayanagi

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.

本文言語English
ページ(範囲)87-88
ページ数2
ジャーナルInternational Congress Series
1284
DOI
出版ステータスPublished - 2005 9

ASJC Scopus subject areas

  • 医学(全般)

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