Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle

Naoyoshi Minami, Yingyu Li, Qi Guo, Takayuki Kawamura, Nobuyoshi Mori, Makoto Nagasaka, Mika Ogawa, Osamu Ito, Hajime Kurosawa, Masayuki Kanazawa, Masahiro Kohzuki

研究成果: Article査読

18 被引用数 (Scopus)

抄録

OBJECTIVE: Physical fitness is closely related with cardiovascular health. We examined the effects of angiotensin-converting enzyme inhibitor, exercise training and their combination on exercise capacity as well as skeletal muscle fiber type and capillarity in spontaneously hypertensive rats (SHR). METHODS: Seven-week-old male SHR were allocated to four groups: sedentary control (C), treatment with perindopril (3 mg/kg per day) (Per), exercise training on a treadmill (EX), and their combination (Per + EX). Following 8-week interventions, rats were submitted to a stepwise exercise test on a treadmill. After experiments, fiber type and capillarity in soleus muscle were examined. RESULTS: Exercise capacity significantly increased in Per compared with in C. Combination of exercise training and perindopril further increased exercise capacity compared with perindopril alone, whereas there was no significant difference in exercise capacity between EX and Per + EX. Capillary density increased similarly in Per and EX compared with in C. Combination of exercise training and perindopril further increased capillary density compared with exercise training alone. The percentage of type I fiber increased only in Per + EX. CONCLUSIONS: We found that in growing SHR, chronic treatment with perindopril enhances untrained exercise capacity, while it does not affect acquired exercise capacity as a result of exercise training. We also found that perindopril promotes adaptive changes of skeletal muscle in response to exercise such as increases in capillary density and percentage of type I fiber.

本文言語English
ページ(範囲)1241-1248
ページ数8
ジャーナルJournal of hypertension
25
6
DOI
出版ステータスPublished - 2007 6

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学

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