Effects of ammonium chloride-induced acidosis on oxidative metabolism in liver mitochondria of chicks

M. Toyomizu, S. Yamahira, M. Tanaka, Y. Akiba

研究成果: Article査読

2 被引用数 (Scopus)

抄録

1. The present studies were undertaken to characterise oxidative metabolism with diverse substrates in hepatic mitochondria of acidotic chicks. Metabolic acidosis was experimentally induced by replacement of drinking water with ammonium chloride solution (15 g/1) for 5 d. 2. State 3 oxidation rates in liver mitochondria were significantly reduced in acidotic chicks only for pyruvate and glutamate as substrates requiring complex I, III and IV of the electron transport chain, while they were not changed for either succinate-requiring complexes II, III and IV, ascorbate+TMPD-requiring complex IV, or α-ketoglutarate requiring complexes I, III and IV. 3. It can be concluded that the impairment of oxidation rate was substrate-specific in liver mitochondria of acidotic animals and not associated with functional damage of the respiratory chain in mitochondria. Possible reasons for the reductions in oxidation rate with pyruvate and glutamate are discussed.

本文言語English
ページ(範囲)541-544
ページ数4
ジャーナルBritish Poultry Science
40
4
DOI
出版ステータスPublished - 1999 1 1

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology

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