Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs

Kimiya Masada, Takahiro Nagayama, Akio Hosokawa, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh

研究成果: Article

21 引用 (Scopus)

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We examined the effects of proadrenomedullin-derived peptides on the release of adrenal catecholamines in response to cholinergic stimuli in pentobarbital sodium-anesthetized dogs. Drugs were administered into the adrenal gland through the phrenicoabdominal artery. Splanchnic nerve stimulation (1, 2, and 3 Hz) and ACh injection (0.75, 1.5, and 3 μg) produced frequency- or dose-dependent increases in adrenal catecholamine output. These responses were unaffected by infusion of adrenomedullin (1, 3, and 10 ng · kg-1 · min-1) or its selective antagonist adrenomedullin- (22-52) (5, 15, and 50 ng · kg-1 · min-1). Proadrenomedullin NH2- terminal 20 peptide (PAMP; 5, 15; and 50 ng · kg-1 · min-1) suppressed both the splanchnic nerve stimulation- and ACh-induced increases in catecholamine output in a dose-dependent manner. PAMP also suppressed the catecholamine release responses to the nicotinic agonist 1,1-dimethyl-4- phenylpiperazinium (0.5, 1, and 2 μg) and to muscarine (0.5, 1, and 2 μg), although the muscarine-induced response was relatively resistant to PAMP. These results suggest that PAMP, but not adrenomedullin, can act as an inhibitory regulator of adrenal catecholamine release in vivo.

元の言語English
ページ(範囲)R1118-R1124
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
276
発行部数4 45-4
DOI
出版物ステータスPublished - 1999 4

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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