Effects of β-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP (81-145) were studied. The dissociation constant was found to be fairly large, which provided evidence against the initial hypothesis. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the β-sheet breaker peptide was not specific and may not play a major role in the inhibition of PrP formation.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry