Effect of ZnO addition on bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics containing apatite and wollastonite

M. Kamitakahara, C. Ohtsuki, H. Inada, M. Tanihara, T. Miyazaki

研究成果: Article査読

62 被引用数 (Scopus)


Some ceramics show bone-bonding ability, i.e. bioactivity. Apatite formation on ceramics is an essential condition to bring about direct bonding to living bone when implanted into bony defects. A controlled surface reaction of the ceramic is an important factor governing the bioactivity and biodegradation of the implanted ceramic. Among bioactive ceramics, glass-ceramic A-W containing apatite and wollastonite shows high bioactivity, as well as high mechanical strength. In this study, glass-ceramics containing zinc oxide were prepared by modification of the composition of the glass-ceramic A-W. Zinc oxide was selected to control the reactivity of the glass-ceramics since zinc is a trace element that shows stimulatory effects on bone formation. Glass-ceramics were prepared by heat treatment of glasses with the general composition: xZnO · (57.0 - x)CaO · 35.4SiO2 · 7.2P2O5 · 0.4CaF2 (where x = 0-14.2 mol.%). Addition of ZnO increased the chemical durability of the glass-ceramics, resulting in a decrease in the rate of apatite formation in a simulated body fluid. On the other hand, the release of zinc from the glass-ceramics increased with increasing ZnO content. Addition of ZnO may provide bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics with the capacity for appropriate biodegradation, as well as enhancement of bone formation.

ジャーナルActa Biomaterialia
出版ステータスPublished - 2006 7月

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生体材料
  • 生化学
  • 生体医工学
  • 分子生物学


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