Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally

Minoru Kawamura, Masahiko Owada, Jun Ino, Takashi Sugawara, Tatsuya Nakano, Izumi Mochizuki, Tsutomu Sakuma, Toshie Segawa, Itaru Motegi, Hironobu Sasano

研究成果: Article査読

抄録

A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in amelio-rating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production.

本文言語English
ページ(範囲)507-512
ページ数6
ジャーナルInternal Medicine
42
6
DOI
出版ステータスPublished - 2003 6 1
外部発表はい

ASJC Scopus subject areas

  • 内科学

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