Effect of threshold on the correlation between airflow obstruction and low attenuation volume in smokers assessed by inspiratory and expiratory MDCT

Noriyuki Yanagawa, Naoko Kawata, Yukiko Matsuura, Toshihiko Sugiura, Toshio Suzuki, Hajime Kasai, Ryosuke Irie, Ken Iesato, Yuji Tada, Nobuhiro Tanabe, Yoichi Suzuki, Koichiro Tatsumi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Background The estimation of emphysematous changes is very sensitive to computed tomography (CT) threshold level. In clinical practice, the predetermined threshold is usually set at -950 Hounsfield units (HU) for the detection of low attenuation volume (LAV). However, threshold levels that are tightly connected to pulmonary function abnormalities have not been determined. Purpose To determine the threshold level for calculating an LAV that closely reflects airflow limitation in patients with chronic obstructive pulmonary disease (COPD). Material and Methods Seventy-six consecutive non-COPD smokers and COPD patients underwent paired inspiratory and expiratory multidetector CT (MDCT). LAV% was segmented every 10 HU between -1000 and -750 HU to examine the correlation between LAV% and indexes of obstructive impairment. Results LAV% gradually increased as the threshold level increased on both inspiratory and expiratory images. LAV% on inspiratory images was higher than that on expiratory images at all threshold levels between -1000 and -750 HU. The threshold level that correlated with obstructive impairment differed between the two images: -930 HU on inspiratory and -870 or -880 HU on expiratory images. Conclusion LAV% dramatically changed according to the threshold level on both inspiratory and expiratory images, indicating that LAV% is dependent on the attenuation threshold level in patients with COPD. The threshold linking LAV% to airflow limitation was higher on expiratory than on inspiratory images.

本文言語English
ページ(範囲)438-446
ページ数9
ジャーナルActa Radiologica
56
4
DOI
出版ステータスPublished - 2015 4月 1

ASJC Scopus subject areas

  • 放射線技術および超音波技術
  • 放射線学、核医学およびイメージング

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