Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics

Masanobu Kamitakahara, Eri Tatsukawa, Yasuaki Shibata, Shota Umemoto, Taishi Yokoi, Koji Ioku, Tohru Ikeda

研究成果: Article査読

9 被引用数 (Scopus)

抄録

In addition to calcium phosphate-based ceramics, glass-based materials have been utilized as bone substitutes, and silicate in these materials has been suggested to contribute to their ability to stimulate bone repair. In this study, a silicate-containing α-tricalcium phosphate (α-TCP) ceramic was prepared using a wet chemical process. Porous granules composed of silicate-containing α-TCP, for which the starting composition had a molar ratio of 0.05 for Si/(P + Si), and silicate-free α-TCP were prepared and evaluated in vivo. When implanted into bone defects that were created in rat femurs, α-TCP ceramics either with or without silicate were biodegraded, generating a hybrid tissue composed of residual ceramic granules and newly formed bone, which had a tissue architecture similar to physiological trabecular structures, and aided regeneration of the bone defects. Supplementation with silicate significantly promoted osteogenesis and delayed biodegradation of α-TCP. These results suggest that silicate-containing α-TCP is advantageous for initial skeletal fixation and wound regeneration in bone repair.

本文言語English
論文番号97
ジャーナルJournal of Materials Science: Materials in Medicine
27
5
DOI
出版ステータスPublished - 2016 5 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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