Effect of scanning the focus on generating cavitation bubbles and reactive oxygen species by using trigger high-intensity focused ultrasound sequence

Shinya Nishitaka, Daisaku Mashiko, Shin Yoshizawa, Shin Ichiro Umemura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

In the sonodynamic treatment, reactive oxygen species (ROS) are generated to damage cancer cells. The efficient generation of ROS, therefore, is significant for the treatment. The trigger high-intensity focused ultrasound (HIFU) sequence, consisting of an extremely high intensity short trigger pulse followed by a medium-intensity and long sustaining burst, was tested for this purpose, with and without scanning the focus, in this study. The distribution of generated cavitation bubbles was observed using a high-speed camera and the amount of generated ROS was quantitatively determined by the KI method. As a result, the trigger HIFU sequence generated several times more ROS than the trigger pulse alone, and the sequence with scanning the focus generated more than twice the amount of ROS than that without scanning the focus when the intermission time between the trigger pulse and the sustaining burst was considered. These suggest that the trigger HIFU sequence with scanning the focus is efficient for generating ROS.

本文言語English
論文番号07LF25
ジャーナルJapanese journal of applied physics
57
7
DOI
出版ステータスPublished - 2018 7

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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