TY - JOUR
T1 - Effect of preparative conditions on crystallinity of apatite particles obtained from simulated body fluids
AU - Hashizume, Mineo
AU - Nagasawa, Yuka
AU - Suzuki, Tomohiko
AU - Kawashima, Shin
AU - Kamitakahara, Masanobu
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Preparation of colloidal hydroxyapatite (HAp) particles under body fluid conditions was investigated with focusing on the effect of preparative conditions on crystallinity of the resulting particles. Tris(hydroxymethyl)aminomethane was added to 1.5SBF (a solution having 1.5 times higher ion concentrations than those of a simulated body fluid, SBF) to increase the solution pH, which resulted in induction of homogeneous nucleation of HAp in the solution. Colloidal HAp particles having diameters about 300. nm were obtained. When the reaction was proceeded at 70 °C and the sample was dried by heating, it was effective to obtain HAp particles having high crystallinity. Experimental results support that remaining water in the sample contributed to increase HAp crystallinity.
AB - Preparation of colloidal hydroxyapatite (HAp) particles under body fluid conditions was investigated with focusing on the effect of preparative conditions on crystallinity of the resulting particles. Tris(hydroxymethyl)aminomethane was added to 1.5SBF (a solution having 1.5 times higher ion concentrations than those of a simulated body fluid, SBF) to increase the solution pH, which resulted in induction of homogeneous nucleation of HAp in the solution. Colloidal HAp particles having diameters about 300. nm were obtained. When the reaction was proceeded at 70 °C and the sample was dried by heating, it was effective to obtain HAp particles having high crystallinity. Experimental results support that remaining water in the sample contributed to increase HAp crystallinity.
KW - Colloidal particle
KW - Homogeneous nucleation
KW - Hydroxyapatite (HAp)
KW - Simulated body fluid (SBF)
UR - http://www.scopus.com/inward/record.url?scp=79952818018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952818018&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2011.02.014
DO - 10.1016/j.colsurfb.2011.02.014
M3 - Article
C2 - 21371868
AN - SCOPUS:79952818018
SN - 0927-7765
VL - 84
SP - 545
EP - 549
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 2
ER -