Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes

Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Cells respond to the circumstances such as structures and chemical composition of scaffolds and cytokine. In this report, the responses of cytoskeleton and spreading of cardiac myocytes to the self-organized honeycomb-patterned films (honeycomb films) of biodegradable poly(ε-caprolactone) (PCL) with several pore sizes were investigated. The expression of actin filament of cardiac myocytes was strongly dependent on the pore size ranging from 4 to 13 μm. Immunofluorescent labeling of vinculin in cardiac myocytes showed localization of focal contact along the edge of the honeycomb pores. The results indicated that the honeycomb structures and the pore sizes influence the morphology, cytoskeletal organization and focal adhesion of the cardiac myocytes.

本文言語English
ページ(範囲)530-535
ページ数6
ジャーナルColloids and Surfaces A: Physicochemical and Engineering Aspects
313-314
DOI
出版ステータスPublished - 2008 2月 1
外部発表はい

ASJC Scopus subject areas

  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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