TY - JOUR
T1 - Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model
AU - Watanabe, Ayaka
AU - Tanaka, Hiroki
AU - Sakurai, Yu
AU - Tange, Kota
AU - Nakai, Yuta
AU - Ohkawara, Tatsuya
AU - Takeda, Hiroshi
AU - Harashima, Hideyoshi
AU - Akita, Hidetaka
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers 15H01806 and 15K14934 . A.W. is supported by The Ministry of Education, Culture, Sports, Science and Technology through Program for Leading Graduate Schools (Hokkaido University “Ambitious Leader’s Program”). H.A. is also supported by Takeda Science Foundation and The Asahi Glass Foundation . The authors also wish to thank Dr. M. S. Feather for his helpful advice in writing the English manuscript
Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/7/25
Y1 - 2016/7/25
N2 - Taking advantage of the enhanced permeation and retention (EPR) effect is a promising approach for delivering macromolecules or nanoparticles to tumors. Recent studies revealed that this strategy is also applicable for targeting other pathological lesions (i.e. inflammatory disease). In the present study, we report the optimal size of a nanoparticle for allowing the higher accumulation of a particle in an inflammatory lesion using a dextran sulfate sodium (DSS)-induced colitis model. As a nanoparticle platform, we utilized a SS-cleavable and pH-activated lipid-like material (ssPalm), that can be used to produce particles in a variety of sizes ranging from 50 nm to 180 nm while using the same lipid composition. In healthy mice, particle accumulation remained low regardless of size. In contrast, the accumulation in inflammatory colon tissue was enhanced depending on the progress of the inflammation. In this situation, the apparent uptake clearance accumulation of a mid-sized particle (113 nm on average) was higher than that for smaller and larger (54 nm and 183 nm in average, respectively) ones. Therefore, controlling particle size is an important parameter for the extensive targeting of inflammatory lesion.
AB - Taking advantage of the enhanced permeation and retention (EPR) effect is a promising approach for delivering macromolecules or nanoparticles to tumors. Recent studies revealed that this strategy is also applicable for targeting other pathological lesions (i.e. inflammatory disease). In the present study, we report the optimal size of a nanoparticle for allowing the higher accumulation of a particle in an inflammatory lesion using a dextran sulfate sodium (DSS)-induced colitis model. As a nanoparticle platform, we utilized a SS-cleavable and pH-activated lipid-like material (ssPalm), that can be used to produce particles in a variety of sizes ranging from 50 nm to 180 nm while using the same lipid composition. In healthy mice, particle accumulation remained low regardless of size. In contrast, the accumulation in inflammatory colon tissue was enhanced depending on the progress of the inflammation. In this situation, the apparent uptake clearance accumulation of a mid-sized particle (113 nm on average) was higher than that for smaller and larger (54 nm and 183 nm in average, respectively) ones. Therefore, controlling particle size is an important parameter for the extensive targeting of inflammatory lesion.
KW - Accumulation
KW - Colitis
KW - Inflammation
KW - Nanoparticles
KW - ssPalm
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U2 - 10.1016/j.ijpharm.2016.05.043
DO - 10.1016/j.ijpharm.2016.05.043
M3 - Article
C2 - 27231121
AN - SCOPUS:84973326032
VL - 509
SP - 118
EP - 122
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -