Effect of nicotine on cognitive disturbance in animals with acetylcholine deficient brain

H. Sasaki, K. I. Meguro, Y. Matsuzaki, C. Doi, S. Yamaguchi, T. Nakamura, T. Aoki, K. Sekizawa, Y. Shimizu

研究成果: Article査読

抄録

The effect of nicotine on learning disturbance was tested in rats fed with a choline-deficient diet (Ch free) or in senescence-accelerated mice (SAM). Concentration of acetylcholine in the brain was significantly lower in rats fed with Ch free and SAM. Passive avoidance learning shows that rats fed with Ch free and SAM showed significantly impaired learning, compared to controls. Nicotine (0.04 mg/kg) administered intraperitonealy significantly improved learning in animals with learning disturbances, as well as in controls. Vitamin B12 facilitated acetylcholine synthesis or release in the brain and improved the cognitive disturbance. We therefore suggest that acetylcholine contributes to learning and that nicotine may improve learning in an acetylcholine deprived rats.

本文言語English
ページ(範囲)143-147
ページ数5
ジャーナルJapanese Journal of Psychopharmacology
13
3
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • 医学(全般)

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