Effect of mesenteric venous volatile fatty acids (VFA) infusion on GH secretion in sheep

Nobuyoshi Matsunaga, Issei Kubota, Sang Gun Roh, Mao Long He, Satoshi Hidaka, Hisashi Hidari, Yasuyuki Sasaki

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The effects of mesenteric venous infusion of acetate, propionate and butyrate mixture (20.3, 40.5 and 81.0 μmol kg-1 min-1 over 4 h) on the secretion of GH was examined to investigate the effects of an increase in portal volatile fatty acids (VFA) on GH secretion in relation to inhibition of GH secretion after feeding in sheep. The mesenteric venous infusion at the rate of 40.5 μmol kg-1 min-1 increased the portal plasma VFA concentration within the approximate physiological range after feeding. Plasma GH was noticeably suppressed only at the infusion rate of 81.0 μmol kg-1 min-1 and the change in the mean concentration from the base line was significantly less than in the control. Although GRF injection rapidly increased plasma GH, the change in the mean concentration from the base line tended to suppress only at the infusion rate of 81.0 μmol kg-1 min-1. Plasma FFA was suppressed in a dose-dependent manner after VFA infusion. The change in the mean concentration from the base line was significantly suppressed only at the infusion rate of 81.0 μmol kg-1 min-1 relative to the control infusion, but plasma glucose was unchanged by VFA infusion. It is concluded that because the increase in the portal plasma VFA concentration within the range of feeding did not suppress GH secretion, VFA absorbed by the digestive tract may not play a significant role in suppressing GH secretion after feeding in sheep.

本文言語English
ページ(範囲)707-714
ページ数8
ジャーナルendocrine journal
44
5
DOI
出版ステータスPublished - 1997 10月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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