Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido; Yasuko Satoh; Akira Naganuma; Nobumasa Imura

doi:10.1016/0378-4274(88)90156-7

Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido, Yasuko Satoh, Akira Naganuma, Nobumasa Imura

薬学研究科・生命薬科学専攻

研究成果: Article › 査読

4 被引用数 (Scopus)

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The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

本文言語	English
ページ（範囲）	153-157
ページ数	5
ジャーナル	Toxicology Letters
巻	40
号	2
DOI	https://doi.org/10.1016/0378-4274(88)90156-7
出版ステータス	Published - 1988 2月

ASJC Scopus subject areas

毒物学

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10.1016/0378-4274(88)90156-7

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title = "Effect of maternal selenium deficiency on the teratogenicity of methylmercury",

abstract = "The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.",

keywords = "Dietary selenium deficiency, Fetotoxicity of methylmercury, Methylmercury-induced cleft palate",

author = "Noriko Nishikido and Yasuko Satoh and Akira Naganuma and Nobumasa Imura",

note = "Funding Information: This study was supported in part by a grant from Uehara Memorial Japan.",

year = "1988",

month = feb,

doi = "10.1016/0378-4274(88)90156-7",

language = "English",

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T1 - Effect of maternal selenium deficiency on the teratogenicity of methylmercury

AU - Nishikido, Noriko

AU - Satoh, Yasuko

AU - Naganuma, Akira

AU - Imura, Nobumasa

N1 - Funding Information: This study was supported in part by a grant from Uehara Memorial Japan.

PY - 1988/2

Y1 - 1988/2

N2 - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

AB - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

KW - Dietary selenium deficiency

KW - Fetotoxicity of methylmercury

KW - Methylmercury-induced cleft palate

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VL - 40

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EP - 157

JO - Toxicology Letters

JF - Toxicology Letters

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Effect of maternal selenium deficiency on the teratogenicity of methylmercury

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