Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido, Yasuko Satoh, Akira Naganuma, Nobumasa Imura

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

本文言語English
ページ(範囲)153-157
ページ数5
ジャーナルToxicology Letters
40
2
DOI
出版ステータスPublished - 1988 2月

ASJC Scopus subject areas

  • 毒物学

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