Effect of macrophages on in vitro corrosion behavior of magnesium alloy

Jian Zhang, Sachiko Hiromoto, Tomohiko Yamazaki, Jialin Niu, Hua Huang, Gaozhi Jia, Haiyan Li, Wenjiang Ding, Guangyin Yuan

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The influence of cells on the corrosion behavior of biomedical magnesium alloy is an important but less studied topic, which is helpful for understanding the inconsistent corrosion rates between in vitro and in vivo experiments. In this work, macrophages were directly cultured on Mg–2.1Nd–0.2Zn–0.5Zr (wt %, abbreviated as JDBM) alloy surface for 72 or 168 hours. Macrophages retained good viability and the generation of reactive oxygen species (ROS) was greatly promoted on the alloy. Weight loss, Mg2+ concentration, and cross-section observation results demonstrated that macrophages accelerated the in vitro corrosion of JDBM. The coverage of cell body did not affect the local thickness of corrosion product layer. The corrosion product layer had a porous inner Mg(OH)2 layer and a dense outer layer mainly composed of O, P, Mg, and Ca. The uniform acceleration of JDBM corrosion was attributed to the omnidirection diffusion of ROS from macrophages.

本文言語English
ページ(範囲)2476-2487
ページ数12
ジャーナルJournal of Biomedical Materials Research - Part A
104
10
DOI
出版ステータスPublished - 2016 10月 1
外部発表はい

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

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