Effect of lectins on the transport of food factors in Caco-2 cell monolayers

Yumiko Ohno, Takako Naganuma, Tomohisa Ogawa, Koji Muramoto

    研究成果: Article査読

    34 被引用数 (Scopus)


    The effect of three plant lectins, soybean lectin (SBA), Japanese jack bean lectin (CGA), and wheat germ lectin (WGA), on the transport of various food factors, such as isoflavones, quercetin, dipeptides, and calcium ions, were investigated by use of an intestinal tract model, Caco-2 cell monolayers. The lectins increased the isoflavone transport but had no effect on aglycon transport. SBA increased the transport of quercetin glycosides, whereas CGA and WGA had no effect. The lectins increased the transport of calcium ions but showed no effect on the transport of dipeptides, carnosine, and anserine. Although SBA did not change the transepithelial electrical resistance (TER) value of the Caco-2 cell monolayers, CGA and WGA decreased the TER value. These results indicate that plant lectins affect the transport of food factors in different manners, presumably due to their specific sugar binding activity.

    ジャーナルJournal of Agricultural and Food Chemistry
    出版ステータスPublished - 2006 1月 25

    ASJC Scopus subject areas

    • 農業および生物科学(その他)
    • 食品科学
    • 化学(その他)


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